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Chaperone Like Attributes of Biogenic Fluorescent Gold Nanoparticles: Potential to Alleviate Toxicity Induced by Intermediate State Fibrils Against Neuroblastoma Cells.
- Source :
-
Frontiers in chemistry [Front Chem] 2019 Nov 19; Vol. 7, pp. 787. Date of Electronic Publication: 2019 Nov 19 (Print Publication: 2019). - Publication Year :
- 2019
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Abstract
- In general, neurodegenerative disorders have a great deal of correlation with the misfolded as well as aggregated forms of protein-based macromolecules. Among various species formed during the aggregation process, protein oligomers have been classified as most toxic entities against several types of living cells. A series of chemicals have been developed to inhibit protein aggregation as a measure to regulate neurodegenerative diseases. Recently, various classes of nanoparticles have also been reported to inhibit protein aggregation. In the present study, we synthesized fluorescent gold nanoparticles (B-AuNPs) employing Olax scandens leaf extract. Next, an in vitro study was performed to assess the effect of as-synthesized B-AuNPs on the aggregation behavior of the ovalbumin (OVA) and other related model proteins. We performed an extensive study to elucidate anti-amyloidogenic properties of nano-sized entities and established that small-sized B-AuNPs manifest chaperone potential against protein aggregation. Further, we exploited as-synthesized B-AuNPs as a mean to prevent protein aggregation mediated toxicity in neuroblastoma cells.<br /> (Copyright © 2019 Mujeeb, Alam, Alshameri, Jamal, Farheen, Kashif, Ahmed, Ghazi and Owais.)
Details
- Language :
- English
- ISSN :
- 2296-2646
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Frontiers in chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 31799242
- Full Text :
- https://doi.org/10.3389/fchem.2019.00787