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Lack of Association between Periodic Limb Movements during Sleep and Neuroimaging Signatures of Cerebral Small Vessel Disease in Stroke-Free Community-Dwelling Older Adults. The Atahualpa Project.
- Source :
-
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2020 Feb; Vol. 29 (2), pp. 104497. Date of Electronic Publication: 2019 Dec 04. - Publication Year :
- 2020
-
Abstract
- Background: Evidence of the relationship between periodic limb movements during sleep (PLMS) and cerebral small vessel disease (cSVD) is limited and inconsistent. Here, we aimed to assess the independent association between PLMS and the different neuroimaging signatures of cSVD.<br />Methods: Atahualpa residents aged more than or equal to 60 years enrolled in the Atahualpa Project undergoing polysomnography and MRI with time intervals less than or equal to 6 months were included. MRI readings focused on white matter hyperintensities (WMH) of presumed vascular origin, deep cerebral microbleeds (CMB), silent lacunar infarcts (LI), and more than 10 enlarged basal ganglia-perivascular spaces (BG-PVS). Data from single-night polysomnograms were interpreted according to recommendations of the American Academy of Sleep Medicine. Associations between the PLMS index and neuroimaging signatures of cSVD (as dependent variables) were assessed by means of logistic regression models, adjusted for relevant confounders.<br />Results: A total of 146 individuals (mean age: 71.4 ± 7.5 years; 64% women) were included. A PLMS index more than or equal to 15 per hour were noted in 48 (33%) participants. Moderate-to-severe WMH were present in 33 individuals (23%), deep CMB in 9 (6%), silent LI in 16 (11%), and more than 10 BG-PVS in 44 (30%). In univariate analyses, silent LI (P = .035) and the presence of more than 10 enlarged BG-PVS (P = .034) were significantly higher among participants with a PLMS index more than or equal to 15 per hour. However, fully-adjusted multivariate models showed no significant association between PLMS index more than or equal to 15 per hour and any of the neuroimaging signatures of cSVD.<br />Conclusions: This study shows no independent association between the PLMS index and neuroimaging signatures of cSVD in stroke-free community-dwelling older adults.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Cerebral Small Vessel Diseases epidemiology
Cerebral Small Vessel Diseases physiopathology
Ecuador epidemiology
Female
Humans
Male
Middle Aged
Nocturnal Myoclonus Syndrome diagnosis
Nocturnal Myoclonus Syndrome epidemiology
Polysomnography
Predictive Value of Tests
Risk Assessment
Risk Factors
Rural Health
Cerebral Small Vessel Diseases diagnostic imaging
Independent Living
Lower Extremity innervation
Magnetic Resonance Imaging
Movement
Neuroimaging methods
Nocturnal Myoclonus Syndrome physiopathology
Sleep
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8511
- Volume :
- 29
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
- Publication Type :
- Academic Journal
- Accession number :
- 31810723
- Full Text :
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2019.104497