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Systemic RAGE ligands are upregulated in tuberculosis individuals with diabetes co-morbidity and modulated by anti-tuberculosis treatment and metformin therapy.
- Source :
-
BMC infectious diseases [BMC Infect Dis] 2019 Dec 09; Vol. 19 (1), pp. 1039. Date of Electronic Publication: 2019 Dec 09. - Publication Year :
- 2019
-
Abstract
- Background: Ligands of the receptor for advanced glycation end products (RAGE) are key signalling molecules in the innate immune system but their role in tuberculosis-diabetes comorbidity (TB-DM) has not been investigated.<br />Methods: We examined the systemic levels of soluble RAGE (sRAGE), advanced glycation end products (AGE), S100A12 and high mobility group box 1 (HMGB1) in participants with either TB-DM, TB, DM or healthy controls (HC).<br />Results: Systemic levels of AGE, sRAGE and S100A12 were significantly elevated in TB-DM and DM in comparison to TB and HC. During follow up, AGE, sRAGE and S100A12 remained significantly elevated in TB-DM compared to TB at 2nd month and 6th month of anti-TB treatment (ATT). RAGE ligands were increased in TB-DM individuals with bilateral and cavitary disease. sRAGE and S100A12 correlated with glycated hemoglobin levels. Within the TB-DM group, those with known diabetes (KDM) revealed significantly increased levels of AGE and sRAGE compared to newly diagnosed DM (NDM). KDM participants on metformin treatment exhibited significantly diminished levels of AGE and sRAGE in comparison to those on non-metformin regimens.<br />Conclusions: Our data demonstrate that RAGE ligand levels reflect disease severity and extent in TB-DM, distinguish KDM from NDM and are modulated by metformin therapy.
- Subjects :
- Adult
Aged
Antitubercular Agents therapeutic use
Case-Control Studies
Comorbidity
Diabetes Mellitus blood
Diabetes Mellitus epidemiology
Female
Glycation End Products, Advanced blood
HMGB1 Protein blood
Humans
Hypoglycemic Agents therapeutic use
Male
Middle Aged
Tuberculosis, Pulmonary drug therapy
Tuberculosis, Pulmonary epidemiology
Up-Regulation
Antigens, Neoplasm blood
Diabetes Mellitus drug therapy
Metformin therapeutic use
Mitogen-Activated Protein Kinases blood
S100A12 Protein blood
Tuberculosis, Pulmonary blood
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2334
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 31818258
- Full Text :
- https://doi.org/10.1186/s12879-019-4648-1