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Perception of side effects associated with anticancer treatment in women with breast or ovarian cancer (KEM-GO-1): a prospective trial.
- Source :
-
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2020 Aug; Vol. 28 (8), pp. 3605-3615. Date of Electronic Publication: 2019 Dec 11. - Publication Year :
- 2020
-
Abstract
- Purpose: Due to advances in anticancer treatment and supportive care, patients increasingly complained about nonphysical side effects of chemotherapy and targeted therapy in recent years. Therefore, continuous assessment of side effects and patients' perceptions is important. The aim of this study was to evaluate the identification and severity of side effects perceived by ovarian cancer (OC) and breast cancer (BC) patients undergoing contemporary anticancer therapy.<br />Methods: Between 2015 and 2017, consecutive chemo-naïve OC and BC patients were enrolled in this prospective cohort study. Interviews were performed 12 ± 3 weeks after start of anticancer therapy, and patients were asked to select and rank, according to severity, 72 physical or nonphysical symptoms potentially related to their treatment. Data were analyzed with descriptive statistics.<br />Results: Forty-five OC patients and 98 BC patients completed the interview. Sleeping difficulties were ranked as the most troublesome symptom, followed by concerns about family or partner, and loss of hair. Alopecia was the most predominant side effect for BC patients, whereas OC patients were highly afflicted by numbness in limbs. Chemotherapy alone or in combination with targeted therapy caused pronounced sleep disturbances. Prolonged taxane treatment led to shortness of breath and numbness in limbs. Vomiting was ranked by one and nausea by eight women among the five most bothersome symptoms.<br />Conclusions: Sleep disturbances have lately emerged as the most severe problem in women with OC or BC receiving anticancer therapy. Concerns about family and partner were ranked second in the current study and first in previous investigations.
- Subjects :
- Adult
Aged
Aged, 80 and over
Alopecia chemically induced
Antibodies, Monoclonal, Humanized administration & dosage
Antibodies, Monoclonal, Humanized adverse effects
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Bevacizumab administration & dosage
Bevacizumab adverse effects
Breast Neoplasms psychology
Bridged-Ring Compounds administration & dosage
Bridged-Ring Compounds adverse effects
Carboplatin administration & dosage
Carboplatin adverse effects
Drug-Related Side Effects and Adverse Reactions etiology
Drug-Related Side Effects and Adverse Reactions psychology
Female
Humans
Middle Aged
Nausea chemically induced
Ovarian Neoplasms psychology
Perception
Prospective Studies
Sleep Wake Disorders chemically induced
Taxoids administration & dosage
Taxoids adverse effects
Trastuzumab administration & dosage
Trastuzumab adverse effects
Vomiting chemically induced
Young Adult
Antineoplastic Combined Chemotherapy Protocols adverse effects
Breast Neoplasms drug therapy
Ovarian Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1433-7339
- Volume :
- 28
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 31828488
- Full Text :
- https://doi.org/10.1007/s00520-019-05216-y