Back to Search
Start Over
Chronic inflammation, cardiometabolic diseases and effects of treatment: Psoriasis as a human model.
- Source :
-
Trends in cardiovascular medicine [Trends Cardiovasc Med] 2020 Nov; Vol. 30 (8), pp. 472-478. Date of Electronic Publication: 2019 Nov 20. - Publication Year :
- 2020
-
Abstract
- Chronic inflammation in humans is associated with accelerated development of cardiometabolic diseases such as myocardial infarction, stroke, and diabetes. Strong evidence from animal models and human interventional trials including CANTOS (The Canakinumab Anti-inflammatory Thrombosis Outcome Study) suggests that targeting residual systemic inflammation in humans may impart a benefit in reducing cardiometabolic diseases. Diseases associated with heightened immune-activation and systemic inflammation including psoriasis, rheumatoid arthritis, systemic lupus erythematosus, and human immunodeficiency virus infection are associated with upwards of two to seven-fold risk of future adverse cardiac events even when adjusted for traditional risk factors. Over the past decade, psoriasis has been utilized as a human model to study inflammatory-induced cardiometabolic dysfunction and to better understand residual risk due to inflammation. The high prevalence and early onset of cardiovascular disease in psoriasis enhances the likelihood of discovering novel pathways in vascular disease progression when followed over time. Furthermore, the United States Food and Drug Administration approved treatments for psoriasis include cytokine inhibitors (anti-tumor necrosis factor, anti-interleukin 17, anti-interleukin 12/23) which while treating the skin disease provide a unique opportunity to characterize how treating the inflammatory pathways may impact atherosclerosis. Herein, we provide a review of chronic inflammation, cardiometabolic disease associations, and treatment effects with a focus on psoriasis as a human model of study.<br /> (Published by Elsevier Inc.)
- Subjects :
- Animals
Cardiometabolic Risk Factors
Cardiovascular Diseases epidemiology
Cardiovascular Diseases immunology
Cardiovascular Diseases metabolism
Chronic Disease
Cytokines metabolism
Humans
Inflammation epidemiology
Inflammation immunology
Inflammation metabolism
Inflammation Mediators metabolism
Metabolic Syndrome epidemiology
Metabolic Syndrome immunology
Metabolic Syndrome metabolism
Prognosis
Psoriasis epidemiology
Psoriasis immunology
Psoriasis metabolism
Risk Assessment
Signal Transduction
Anti-Inflammatory Agents therapeutic use
Cardiovascular Diseases prevention & control
Cytokines antagonists & inhibitors
Inflammation drug therapy
Inflammation Mediators antagonists & inhibitors
Metabolic Syndrome prevention & control
Psoriasis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2615
- Volume :
- 30
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Trends in cardiovascular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 31837960
- Full Text :
- https://doi.org/10.1016/j.tcm.2019.11.001