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Semen Cuscutae Administration Improves Hepatic Lipid Metabolism and Adiposity in High Fat Diet-Induced Obese Mice.
- Source :
-
Nutrients [Nutrients] 2019 Dec 12; Vol. 11 (12). Date of Electronic Publication: 2019 Dec 12. - Publication Year :
- 2019
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Abstract
- Since arginase has been shown to compete with nitric oxide (NO) synthase, emerging evidence has reported that arginase inhibition improves obesity by increasing NO production. Semen cuscutae (SC), which is a well-known Chinese medicine, has multiple biological functions such as anti-oxidant function and immune regulation. In this study, we investigated whether the SC as a natural arginase inhibitor influences hepatic lipid abnormalities and whole-body adiposity in high-fat diet (HFD)-induced obese mice. The lipid accumulation was significantly reduced by SC treatment in oleic acid-induced hepatic steatosis in vitro. Additionally, SC supplementation substantially lowered HFD-induced increases in arginase activity and weights of liver and visceral fat tissue, while increasing hepatic NO. Furthermore, elevated mRNA expressions of sterol regulatory element-binding transcription factor 1 (SREBP-1c), fatty-acid synthase (FAS), peroxisome proliferator-activated receptor-gamma (PPAR-γ)1, and PPAR-γ2 in HFD-fed mice were significantly attenuated by SC supplementation. Taken together, SC, as a novel natural arginase inhibitor, showed anti-obesity properties by modulating hepatic arginase and NO production and metabolic pathways related to hepatic triglyceride (TG) metabolism.
- Subjects :
- Animals
Arginase antagonists & inhibitors
Cell Culture Techniques
Diet, High-Fat
Fatty Acid Synthase, Type I metabolism
Liver metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Obese
Nitric Oxide biosynthesis
Obesity therapy
PPAR gamma metabolism
Signal Transduction drug effects
Sterol Regulatory Element Binding Protein 1 metabolism
Adiposity drug effects
Cuscuta
Dietary Supplements
Drugs, Chinese Herbal pharmacology
Lipid Metabolism drug effects
Obesity metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 11
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 31842363
- Full Text :
- https://doi.org/10.3390/nu11123035