Back to Search Start Over

Viral Fitness Landscapes in Diverse Host Species Reveal Multiple Evolutionary Lines for the NS1 Gene of Influenza A Viruses.

Authors :
Muñoz-Moreno R
Martínez-Romero C
Blanco-Melo D
Forst CV
Nachbagauer R
Benitez AA
Mena I
Aslam S
Balasubramaniam V
Lee I
Panis M
Ayllón J
Sachs D
Park MS
Krammer F
tenOever BR
García-Sastre A
Source :
Cell reports [Cell Rep] 2019 Dec 17; Vol. 29 (12), pp. 3997-4009.e5.
Publication Year :
2019

Abstract

Influenza A viruses (IAVs) have a remarkable tropism in their ability to circulate in both mammalian and avian species. The IAV NS1 protein is a multifunctional virulence factor that inhibits the type I interferon host response through a myriad of mechanisms. How NS1 has evolved to enable this remarkable property across species and its specific impact in the overall replication, pathogenicity, and host preference remain unknown. Here we analyze the NS1 evolutionary landscape and host tropism using a barcoded library of recombinant IAVs. Results show a surprisingly great variety of NS1 phenotypes according to their ability to replicate in different hosts. The IAV NS1 genes appear to have taken diverse and random evolutionary pathways within their multiple phylogenetic lineages. In summary, the high evolutionary plasticity of this viral protein underscores the ability of IAVs to adapt to multiple hosts and aids in our understanding of its global prevalence.<br /> (Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
2211-1247
Volume :
29
Issue :
12
Database :
MEDLINE
Journal :
Cell reports
Publication Type :
Academic Journal
Accession number :
31851929
Full Text :
https://doi.org/10.1016/j.celrep.2019.11.070