MMP-12 as a potential biomarker to forecast ischemic stroke in obese patients.

Authors :: Wang CY
Zhang CP
Li BJ
Jiang SS
He WH
Long SY
Tian Y
Source :: Medical hypotheses [Med Hypotheses] 2020 Mar; Vol. 136, pp. 109524. Date of Electronic Publication: 2019 Dec 09.
Publication Year :: 2020
Abstract: Human health is threatened by obesity which causes the increasing incidence of various diseases, especially stroke. Ischemic stroke (IS) is mostly caused by the rupture of arterial plaque, whose instability is positively associated with matrix metalloproteinases (MMPs) that degrades extracellular matrix components. Studies have shown that matrix metalloproteinase-12 (MMP-12) may be involved in the pathogenesis of IS. Because of the higher incidence of stroke in obese patients than that in normal weight people, it is urgent for obesity to forecast stroke early. Considering high levels MMP-12 in obesity, we put forward that MMP-12 may be a potential biomarker for IS in obese patients.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)