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Flexible, low volume detection of chronobiology biomarkers from human sweat.
- Source :
-
The Analyst [Analyst] 2020 Feb 03; Vol. 145 (3), pp. 784-796. - Publication Year :
- 2020
-
Abstract
- Chronobiology is defined as the temporal fluctuations occurring in the human physiology due to the circadian cycle. These fluctuations are good indicators of the functioning of the Hypothalamic-Pituitary-Adrenal axis (HPA axis) and can be tracked by using biomarkers: cortisol and DHEA. Low volume tracking systems will be beneficial for patients exposed to chronic stress, patients suffering from endocrine conditions manifested by circadian disruption and act as a lifestyle monitoring tool. The sensor system demonstrated in this work was an affinity-based system, characterized using EIS (Electrochemical Impedance Spectroscopy).The sensor can detect cortisol and DHEA in the physiologically relevant ranges i.e. 8-200 ng ml-1 and 2-131 ng ml-1 respectively. Thus, the senor is a non-invasive, label free, cost-effective solution for tracking chronobiology for circadian diagnostics.
Details
- Language :
- English
- ISSN :
- 1364-5528
- Volume :
- 145
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Analyst
- Publication Type :
- Academic Journal
- Accession number :
- 31867585
- Full Text :
- https://doi.org/10.1039/c9an01968e