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Enzyme-responsive fluorescent camptothecin prodrug/polysaccharide supramolecular assembly for targeted cellular imaging and in situ controlled drug release.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Jan 23; Vol. 56 (7), pp. 1042-1045. - Publication Year :
- 2020
-
Abstract
- A novel enzyme-responsive supramolecular polysaccharide assembly composed of disulfide linked adamantane-naphthalimide fluorescent camptothecin prodrug (AdaCPT) and β-CD modified hyaluronic acid (HACD) was constructed, possessing low cellular cytotoxicity and exhibiting targeted cellular imaging and controlled drug release at specific sites while providing a concurrent means for the real-time tracking of drug delivery.
- Subjects :
- Adamantane analogs & derivatives
Adamantane chemical synthesis
Adamantane pharmacology
Adamantane toxicity
Animals
Antineoplastic Agents chemical synthesis
Antineoplastic Agents toxicity
Camptothecin chemical synthesis
Camptothecin toxicity
Drug Liberation
Fluorescent Dyes chemical synthesis
Fluorescent Dyes toxicity
HCT116 Cells
Humans
Hyaluronic Acid chemistry
Mice
Microscopy, Confocal methods
Microscopy, Fluorescence methods
NIH 3T3 Cells
Naphthalimides chemical synthesis
Naphthalimides pharmacology
Naphthalimides toxicity
Prodrugs chemical synthesis
Prodrugs toxicity
beta-Cyclodextrins chemistry
Antineoplastic Agents pharmacology
Camptothecin pharmacology
Drug Carriers chemistry
Fluorescent Dyes pharmacology
Prodrugs pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 56
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 31868189
- Full Text :
- https://doi.org/10.1039/c9cc08491f