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The role of estrogens in the adipose tissue milieu.

Authors :
Bracht JR
Vieira-Potter VJ
De Souza Santos R
Öz OK
Palmer BF
Clegg DJ
Source :
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2020 Feb; Vol. 1461 (1), pp. 127-143. Date of Electronic Publication: 2019 Dec 23.
Publication Year :
2020

Abstract

One of the leading causes for the development of adverse metabolic effects, including type 2 diabetes, dyslipidemia, and cardiovascular diseases, is the accumulation of excess body weight, often measured by body mass index (BMI). Although BMI, calculated using weight and height, is the standard measure used to determine body adiposity in clinical and public health guidelines, an inherent limitation is that BMI does not distinguish where in the body adiposity is deposited. Central obesity, characterized by greater accumulation of adiposity in the abdominal region, has been associated with a higher risk of mortality, independent of BMI. Importantly, one of the determinants of body fat distribution is sex hormones. Both estrogens and androgens appear to directly and indirectly influence body fat distribution. Our review will focus specifically on the role of estrogens and their influence in determining body fat distribution and overall health of adipose tissues, and the role of epigenetic mechanisms in regulating the production and function of estrogens.<br /> (© 2019 New York Academy of Sciences.)

Details

Language :
English
ISSN :
1749-6632
Volume :
1461
Issue :
1
Database :
MEDLINE
Journal :
Annals of the New York Academy of Sciences
Publication Type :
Academic Journal
Accession number :
31868931
Full Text :
https://doi.org/10.1111/nyas.14281