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Associations of SRD5A1 gene variants and testosterone with dysglycemia: Henan Rural Cohort study.
- Source :
-
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2020 Apr 12; Vol. 30 (4), pp. 599-607. Date of Electronic Publication: 2019 Nov 28. - Publication Year :
- 2020
-
Abstract
- Background and Aim: Multiple studies support a complex relationship between testosterone and type 2 diabetes mellitus (T2DM) and the transformation of testosterone is affected by several reductases. Thus, we aimed to explore the associations of steroid-5α-reductase type 1 (SRD5A1) gene polymorphism with impaired fasting glucose (IFG) and T2DM and the interactive effects of testosterone and genotypes on glycometabolism.<br />Methods and Results: A case-control study including 2365 participants was performed. Genomic DNA was extracted from the whole blood and genotyped for the SRD5A1 single nucleotide polymorphisms (SNP) rs1691053. Multivariable logistic regression and linear regression were performed to estimate the associations of SRD5A1 rs1691053 alleles and genotypes with glycometabolism. Generalized linear models were used to investigate the modulatory effects of serum testosterone on glycometabolism indexes in males. After multivariable adjustment, the odds ratio (OR) of homozygous CC genotypes in male carriers was 2.62 (95%CI: 1.11-6.18) for IFG. Furthermore, significant associations of SRD5A1 rs1691053 polymorphisms with adverse indices of glycometabolism were observed in males. Interestingly, the opposite associations in females were observed. The interactive associations of SNP and testosterone were found and mutations were more likely to lead unfavorable metabolic phenotypes.<br />Conclusion: These results showed that SRD5A1 rs1691053 gene polymorphism was independently associated with glycometabolism. The interaction between a genetic polymorphism from SRD5A1 and testosterone involved glycometabolism was identified in males. Although this preliminary data should be replicated with other rigorous researches, it highlighted the importance of the SNP-testosterone interaction over the present of glycometabolism.<br />Competing Interests: Declaration of Competing Interest The authors have nothing to disclose.<br /> (Copyright © 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Aged
Asian People genetics
Biomarkers blood
Blood Glucose metabolism
Case-Control Studies
China epidemiology
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 diagnosis
Diabetes Mellitus, Type 2 ethnology
Female
Gene Frequency
Genetic Predisposition to Disease
Glucose Intolerance blood
Glucose Intolerance diagnosis
Glucose Intolerance ethnology
Humans
Male
Middle Aged
Phenotype
Prospective Studies
Risk Assessment
Risk Factors
Rural Health
3-Oxo-5-alpha-Steroid 4-Dehydrogenase genetics
Blood Glucose genetics
Diabetes Mellitus, Type 2 genetics
Glucose Intolerance genetics
Membrane Proteins genetics
Polymorphism, Single Nucleotide
Testosterone blood
Subjects
Details
- Language :
- English
- ISSN :
- 1590-3729
- Volume :
- 30
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nutrition, metabolism, and cardiovascular diseases : NMCD
- Publication Type :
- Academic Journal
- Accession number :
- 31870594
- Full Text :
- https://doi.org/10.1016/j.numecd.2019.11.011