Back to Search Start Over

The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity.

Authors :
Seillet C
Luong K
Tellier J
Jacquelot N
Shen RD
Hickey P
Wimmer VC
Whitehead L
Rogers K
Smyth GK
Garnham AL
Ritchie ME
Belz GT
Source :
Nature immunology [Nat Immunol] 2020 Feb; Vol. 21 (2), pp. 168-177. Date of Electronic Publication: 2019 Dec 23.
Publication Year :
2020

Abstract

Group 3 innate lymphoid cell (ILC3)-mediated production of the cytokine interleukin-22 (IL-22) is critical for the maintenance of immune homeostasis in the gastrointestinal tract. Here, we find that the function of ILC3s is not constant across the day, but instead oscillates between active phases and resting phases. Coordinate responsiveness of ILC3s in the intestine depended on the food-induced expression of the neuropeptide vasoactive intestinal peptide (VIP). Intestinal ILC3s had high expression of the G protein-coupled receptor vasoactive intestinal peptide receptor 2 (VIPR2), and activation by VIP markedly enhanced the production of IL-22 and the barrier function of the epithelium. Conversely, deficiency in signaling through VIPR2 led to impaired production of IL-22 by ILC3s and increased susceptibility to inflammation-induced gut injury. Thus, intrinsic cellular rhythms acted in synergy with the cyclic patterns of food intake to drive the production of IL-22 and synchronize protection of the intestinal epithelium through a VIP-VIPR2 pathway in ILC3s.

Details

Language :
English
ISSN :
1529-2916
Volume :
21
Issue :
2
Database :
MEDLINE
Journal :
Nature immunology
Publication Type :
Academic Journal
Accession number :
31873294
Full Text :
https://doi.org/10.1038/s41590-019-0567-y