Back to Search
Start Over
Achievement of Low-Density Lipoprotein Cholesterol Targets in CKD.
- Source :
-
Kidney international reports [Kidney Int Rep] 2019 Jul 30; Vol. 4 (11), pp. 1546-1554. Date of Electronic Publication: 2019 Jul 30 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Introduction: We describe the characteristics of patients with moderate/advanced chronic kidney disease (CKD) according to receipt of lipid-lowering therapy (LLT), and whether they achieved low-density lipoprotein cholesterol (LDL-C) targets for high- and very high-risk patients.<br />Methods: CKD-REIN (NCT03381950), a prospective cohort study conducted in 40 nephrology clinics in France, enrolled 3033 patients with moderate (stage G3) or advanced (stage G4/G5) CKD (2013-2016) who had not been on chronic dialysis or undergone kidney transplantation. Data were collected from patients' interviews and medical records. Patients were followed up at 1 year.<br />Results: Among 2542 patients (mean [SD] age 67 [13] years, 34% women) with LDL-C measurements at baseline (mean [SD] LDL-C 2.7 [1.1] mmol/l; cholesterol 4.8 [1.3] mmol/l), 63% were on LLT; 24% were at high (CKD stage G3, no cardiovascular disease [CVD] or diabetes) and 74% at very high (CKD stage G3 with diabetes or CVD, or CKD stage G4/5) cardiovascular risk. Among high-risk patients, 45% of those on statin and/or ezetimibe achieved the LDL-C treatment target (<2.6 mmol/l). Among very high-risk patients, the percentage at goal (<1.8 mmol/l) was 38% for CKD stage G3 and 29% for stage G4/5. There was a trend toward higher achievement of LDL-C targets with increasing LLT intensity (adjusted odds ratios for moderate vs. low intensity 1.20; 95% confidence interval 0.92-1.56; high vs. low intensity 1.46; 1.02-2.09; P <subscript>trend</subscript>  = 0.036).<br />Conclusion: Many patients with CKD stage G3-G5 who are eligible for LLT are not treated, and those on LLT rarely achieve LDL-C targets.<br /> (© 2019 International Society of Nephrology. Published by Elsevier Inc.)
Details
- Language :
- English
- ISSN :
- 2468-0249
- Volume :
- 4
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Kidney international reports
- Publication Type :
- Academic Journal
- Accession number :
- 31890996
- Full Text :
- https://doi.org/10.1016/j.ekir.2019.07.014