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Measles in pregnant women: A systematic review of clinical outcomes and a meta-analysis of antibodies seroprevalence.
- Source :
-
The Journal of infection [J Infect] 2020 Feb; Vol. 80 (2), pp. 152-160. Date of Electronic Publication: 2019 Dec 28. - Publication Year :
- 2020
-
Abstract
- Objectives: Pregnant women represent a category at high risk of severe measles infection, that negatively affects the fetus as well. A systematic review of clinical outcomes of measles infection in gravid subjects and a meta-analysis of antibodies prevalence among pregnant women was conducted.<br />Methods: MEDLINE and EMBASE databases were searched up to 18 June 2018. The screening focused on: (i) articles describing the outcome of measles in pregnancy, synthesized in a descriptive fashion; (ii) articles addressing the measles seroprevalence in cohorts of gravid women, analysed quantitatively.<br />Results: Twenty-nine articles met inclusion criteria. A total of 420 cases of measles in gravid subjects were described, from 1941 to 2012. Among women, 18 deaths (4.3%) occurred, and the most frequent complication was pneumonia (75/420, 17.9%). Prematurity was the most important complication concerning fetal outcomes (55 out of 410 cases with available data, 13.4%). The random-effects pooled seroprevalence of measles in 20,546 gravid women worldwide was 89.3% (95% CI: 87.3-91.1%), that decreased, although not in a statistically significant way, over time (p = 0.54).<br />Conclusions: Measles infection in pregnancy is dangerous both for the mother and the foetus. Antibody seroprevalence among gravid women on a global scale is lower than the herd immunity threshold.<br />Competing Interests: Declaration of Competing Interests None.<br /> (Copyright © 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1532-2742
- Volume :
- 80
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of infection
- Publication Type :
- Academic Journal
- Accession number :
- 31891729
- Full Text :
- https://doi.org/10.1016/j.jinf.2019.12.012