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The first case of fingernail onychomycosis due to Neoscytalidium novaehollandiae, molecular identification and antifungal susceptibility.
- Source :
-
Journal de mycologie medicale [J Mycol Med] 2020 Apr; Vol. 30 (1), pp. 100920. Date of Electronic Publication: 2019 Dec 20. - Publication Year :
- 2020
-
Abstract
- Onychomycosis is considered a fungal nail infection caused mainly by dermatophytes, yeasts and non-dermatophyte molds including dematiaceous fungi. Onychomycosis caused by non-dermatophyte molds is a health problem in the medical environment as the patients frequently return to outpatient clinics seeking new therapeutic modalities. Here, we report the first case of onychomycosis caused by a black fungus, Neoscytalidium novaehollandiae, in the right hand finger nail of a 52-year-old Iranian female with no history of immunodeficiency and underlying disease. The pattern of nail involvement was recognized as total dystrophic onychomycosis. Examination of nail scrapings with potassium hydroxide revealed brown, septate and branching sub-hyaline to dark-colored hyphae. The black fungus isolated in culture was identified as Neoscytalidium novaehollandiae by molecular analysis. The patient received oral terbinafine plus ciclopirox nail lacquer twice a week and began responding to the treatment three months after initial antifungal therapy. Additional four weeks' use of terbinafine plus ciclopirox nail lacquer completely resolved the clinical manifestations of onychomycosis. After four months, both microscopy and culture were negative.<br /> (Copyright © 2019 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Antifungal Agents therapeutic use
Drug Resistance, Microbial drug effects
Female
Hand Dermatoses diagnosis
Hand Dermatoses drug therapy
Humans
Immunocompetence
Iran
Microbial Sensitivity Tests
Middle Aged
Molecular Diagnostic Techniques
Mycological Typing Techniques methods
Onychomycosis diagnosis
Onychomycosis drug therapy
Ascomycota drug effects
Ascomycota genetics
Ascomycota isolation & purification
Hand Dermatoses microbiology
Onychomycosis microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1773-0449
- Volume :
- 30
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal de mycologie medicale
- Publication Type :
- Academic Journal
- Accession number :
- 31892498
- Full Text :
- https://doi.org/10.1016/j.mycmed.2019.100920