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Response to tocilizumab and work productivity in patients with rheumatoid arthritis: 2-year follow-up of FIRST ACT-SC study.

Authors :
Tanaka Y
Kameda H
Saito K
Kaneko Y
Tanaka E
Yasuda S
Tamura N
Fujio K
Fujii T
Kojima T
Anzai T
Hamada C
Fujino Y
Matsuda S
Kohsaka H
Source :
Modern rheumatology [Mod Rheumatol] 2021 Jan; Vol. 31 (1), pp. 42-52. Date of Electronic Publication: 2020 Jan 20.
Publication Year :
2021

Abstract

Objectives: We evaluated long-term control of rheumatoid arthritis (RA) in Japanese paid workers (PWs) and house workers (HWs) treated with subcutaneous tocilizumab (TCZ-SC) and explored factors affecting response to TCZ-SC regarding work productivity.<br />Methods: This study collected data from patients with RA in the TCZ-SC +/- conventional synthetic disease-modifying antirheumatic drugs group. Factors affecting the response to tocilizumab regarding work productivity were explored using logistic regression. Differences in quality-adjusted life years (QALYs) between with/without response were analysed by a linear regression.<br />Results: Data were analysed for 357/360 patients. Patients with a ≥ 75% improvement in activity impairment (AI) were considered responders. EuroQol-5 Dimension (EQ-5D), six-item Kessler psychological distress scale score (K6), Health Assessment Questionnaire Disability Index (HAQ-DI), and the patient's disease global health by visual analogue scale were significant contributors to TCZ-SC response based on improvements in AI. Work Functioning Impairment Scale, presenteeism, EQ-5D, K6, and HAQ-DI significantly contributed to the improvement of overall work impairment in PWs. Shorter disease duration also was related to TCZ-SC response based on AI improvements. Responders had significantly larger mean QALYs than non-responders (difference = 0.2614; p  < .001).<br />Conclusions: These real-world clinical data support long-term work productivity control with TCZ-SC for biologic-naïve HWs and PWs with RA.

Details

Language :
English
ISSN :
1439-7609
Volume :
31
Issue :
1
Database :
MEDLINE
Journal :
Modern rheumatology
Publication Type :
Academic Journal
Accession number :
31903822
Full Text :
https://doi.org/10.1080/14397595.2019.1709681