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PTC1 and PTC2: New Indices of Blood Pressure Waveforms and Cardiovascular Disease.
- Source :
-
American journal of epidemiology [Am J Epidemiol] 2020 Jul 01; Vol. 189 (7), pp. 726-734. - Publication Year :
- 2020
-
Abstract
- Systolic and diastolic blood pressures provide information about cardiovascular disease (CVD) but are only extremes of the pressure waveform during the cardiac cycle. We developed summaries of the pressure decay, called PTC1 and PTC2, that are related to arterial compliance and to an existing proprietary summary that has been shown to predict CVD. We derived the summaries from a Windkessel model (consisting of a decaying exponential plus a dampened cosine, with an intercept so they are independent of calibration with blood pressure, unlike the proprietary measures), and we estimated them using nonlinear least squares with standard, free software. Among 6,228 adults from the Multi-Ethnic Study of Atherosclerosis, initially free of CVD in 2000-2002, mean PTC2 was 94 (standard deviation, 46) milliseconds. During median 15-year follow-up, there were 911 CVD events (including 609 incidents of coronary heart disease and 270 strokes). One-standard-deviation higher PTC2 was associated with 17% (95% confidence interval: 10, 24) lower CVD risk, after adjustment for traditional risk factors. Results were similar for PTC1. PTC1 and PTC2 are relatively straightforward to compute and add information beyond traditional risk factors for prediction of CVD. Our work enables others to replicate and extend our results with waveforms from any suitable device.<br /> (© The Author(s) 2020. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Atherosclerosis complications
Cardiovascular Diseases epidemiology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Models, Statistical
Risk Assessment methods
Risk Factors
Atherosclerosis physiopathology
Blood Pressure physiology
Blood Pressure Determination methods
Cardiovascular Diseases etiology
Health Status Indicators
Subjects
Details
- Language :
- English
- ISSN :
- 1476-6256
- Volume :
- 189
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- American journal of epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 31907510
- Full Text :
- https://doi.org/10.1093/aje/kwz280