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Mitochondrion-targeted selenium nanoparticles enhance reactive oxygen species-mediated cell death.
- Source :
-
Nanoscale [Nanoscale] 2020 Jan 23; Vol. 12 (3), pp. 1389-1396. - Publication Year :
- 2020
-
Abstract
- Selenium nanoparticles (SeNPs) can induce reactive oxygen species (ROS)-mediated cell death when accumulated in cancer cells, while rendering anti-oxidation and cancer prevention in healthy tissues at low doses. Although they are promising anticancer agents with fewer side effects, their application is limited by their relative low toxicity to cancer cells. Therefore, we propose a mitochondrion-targeting strategy to improve their cancer cell killing efficiency. Such mitochondrion-targeted SeNPs could efficiently increase ROS production and mitochondrion damage in cancer cells; however, only a slightly increased toxicity to normal cells was observed, indicating a potentially better therapeutic window for anticancer treatments.
- Subjects :
- HeLa Cells
Humans
Mitochondria pathology
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Metal Nanoparticles chemistry
Metal Nanoparticles therapeutic use
Mitochondria metabolism
Neoplasms drug therapy
Neoplasms metabolism
Neoplasms pathology
Reactive Oxygen Species metabolism
Selenium chemistry
Selenium pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2040-3372
- Volume :
- 12
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Nanoscale
- Publication Type :
- Academic Journal
- Accession number :
- 31913383
- Full Text :
- https://doi.org/10.1039/c9nr09039h