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Mitochondrion-targeted selenium nanoparticles enhance reactive oxygen species-mediated cell death.

Authors :
Zhuang Y
Li L
Feng L
Wang S
Su H
Liu H
Liu H
Wu Y
Source :
Nanoscale [Nanoscale] 2020 Jan 23; Vol. 12 (3), pp. 1389-1396.
Publication Year :
2020

Abstract

Selenium nanoparticles (SeNPs) can induce reactive oxygen species (ROS)-mediated cell death when accumulated in cancer cells, while rendering anti-oxidation and cancer prevention in healthy tissues at low doses. Although they are promising anticancer agents with fewer side effects, their application is limited by their relative low toxicity to cancer cells. Therefore, we propose a mitochondrion-targeting strategy to improve their cancer cell killing efficiency. Such mitochondrion-targeted SeNPs could efficiently increase ROS production and mitochondrion damage in cancer cells; however, only a slightly increased toxicity to normal cells was observed, indicating a potentially better therapeutic window for anticancer treatments.

Details

Language :
English
ISSN :
2040-3372
Volume :
12
Issue :
3
Database :
MEDLINE
Journal :
Nanoscale
Publication Type :
Academic Journal
Accession number :
31913383
Full Text :
https://doi.org/10.1039/c9nr09039h