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Imaging of Diastolic Dysfunction in Community-Based Epidemiological Studies and Randomized Controlled Trials of HFpEF.
- Source :
-
JACC. Cardiovascular imaging [JACC Cardiovasc Imaging] 2020 Jan; Vol. 13 (1 Pt 2), pp. 310-326. - Publication Year :
- 2020
-
Abstract
- By assessing nonhospitalized asymptomatic patients, community-based studies inform the prevalence, key clinical characteristics, and outcomes associated with diastolic dysfunction. As the number of parameters to define and grade diastolic function continues to increase, there has been a shift to a focus on readily obtainable measurements with minimal interobserver variability. In this regard, mitral inflow and annular tissue Doppler velocities, as well as measurement of left atrial volume index, are the most feasible and reproducible. Within communities, variations in definitions have limited generalizability regarding the prevalence and risks associated with diastolic dysfunction. Nevertheless, community-based studies have established important associations with hypertension, obesity, and diabetes. Randomized controlled trials of treatment in heart failure with preserved ejection fraction have been disappointing. Importantly, diastolic dysfunction is consistently associated with higher mortality, which emphasizes the importance of early recognition and initiation of appropriate preventative treatments.<br /> (Copyright © 2020. Published by Elsevier Inc.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Diastole
Evidence-Based Medicine
Female
Heart Failure mortality
Heart Failure physiopathology
Heart Failure therapy
Humans
Male
Middle Aged
Predictive Value of Tests
Prognosis
Randomized Controlled Trials as Topic
Risk Factors
Ventricular Dysfunction, Left mortality
Ventricular Dysfunction, Left physiopathology
Ventricular Dysfunction, Left therapy
Ventricular Function, Left
Young Adult
Echocardiography, Doppler
Heart Failure diagnostic imaging
Ventricular Dysfunction, Left diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1876-7591
- Volume :
- 13
- Issue :
- 1 Pt 2
- Database :
- MEDLINE
- Journal :
- JACC. Cardiovascular imaging
- Publication Type :
- Academic Journal
- Accession number :
- 31918900
- Full Text :
- https://doi.org/10.1016/j.jcmg.2019.10.022