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Comparison of post-transplantation diabetes mellitus incidence and risk factors between kidney and liver transplantation patients.
- Source :
-
PloS one [PLoS One] 2020 Jan 10; Vol. 15 (1), pp. e0226873. Date of Electronic Publication: 2020 Jan 10 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- Background: Most prior studies characterizing post-transplantation diabetes mellitus (PTDM) have been limited to single-cohort, single-organ studies. This retrospective study determined PTDM across organs by comparing incidence and risk factors among 346 liver and 407 kidney transplant recipients from a single center.<br />Methods: Univariate and multivariate regression-based analyses were conducted to determine association of various risk factors and PTDM in the two cohorts, as well as differences in glucometrics and insulin use across time points.<br />Results: There was a higher incidence of PTDM among liver versus kidney transplant recipients (30% vs. 19%) at 1-year post-transplant. Liver transplant recipients demonstrated a 337% higher odds association to PTDM (OR 3.37, 95% CI (1.38-8.25), p<0.01). 1-month FBG was higher in kidney patients (135 mg/dL vs 104 mg/dL; p < .01), while 1-month insulin use was higher in liver patients (61% vs 27%, p < .01). Age, BMI, insulin use, and inpatient FBG were also significantly associated with differential PTDM risk.<br />Conclusions: Kidney and liver transplant patients have different PTDM risk profiles, both in terms of absolute PTDM risk as well as time course of risk. Management of this population should better reflect risk heterogeneity to short-term need for insulin therapy and potentially long-term outcomes.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Diabetes Mellitus diagnosis
Diabetes Mellitus drug therapy
Diabetes Mellitus immunology
Female
Humans
Immunosuppression Therapy
Incidence
Insulin therapeutic use
Male
Middle Aged
Prognosis
Retrospective Studies
Risk Factors
Diabetes Mellitus etiology
Kidney Transplantation adverse effects
Liver Transplantation adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 31923179
- Full Text :
- https://doi.org/10.1371/journal.pone.0226873