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Dietary glycaemic index, glycaemic load and head and neck cancer risk: a pooled analysis in an international consortium.
- Source :
-
British journal of cancer [Br J Cancer] 2020 Mar; Vol. 122 (6), pp. 745-748. Date of Electronic Publication: 2020 Jan 13. - Publication Year :
- 2020
-
Abstract
- High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (OR <subscript>Q4 vs. Q1</subscript> = 1.16; 95% CI = 1.02-1.31). In subsites, we found a positive association between GI and laryngeal cancer (OR <subscript>Q4 vs. Q1</subscript> = 1.60; 95% CI = 1.30-1.96) and an inverse association between GL and oropharyngeal cancer (OR <subscript>Q4 vs. Q1</subscript> = 0.78; 95% CI = 0.63-0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer.
Details
- Language :
- English
- ISSN :
- 1532-1827
- Volume :
- 122
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- British journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 31929514
- Full Text :
- https://doi.org/10.1038/s41416-019-0702-4