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Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection.
- Source :
-
Nature communications [Nat Commun] 2020 Jan 14; Vol. 11 (1), pp. 272. Date of Electronic Publication: 2020 Jan 14. - Publication Year :
- 2020
-
Abstract
- Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the response of MAIT cells during acute HIV-1 infection utilizing the RV217 cohort with paired longitudinal pre- and post-infection samples. MAIT cells are activated and expand in blood and mucosa coincident with peak HIV-1 viremia, in a manner associated with emerging microbial translocation. This is followed by a phase with elevated function as viral replication is controlled to a set-point level, and later by their functional decline at the onset of chronic infection. Interestingly, enhanced innate-like pathways and characteristics develop progressively in MAIT cells during infection, in parallel with TCR repertoire alterations. These findings delineate the dynamic MAIT cell response to acute HIV-1 infection, and show how the MAIT compartment initially responds and expands with enhanced function, followed by progressive reprogramming away from TCR-dependent antibacterial responses towards innate-like functionality.
- Subjects :
- Biomarkers blood
Biomarkers metabolism
C-Reactive Protein metabolism
Cohort Studies
HIV-1 physiology
Humans
Immunity, Innate genetics
Interferon Regulatory Factors genetics
Interferon Regulatory Factors metabolism
Lipopolysaccharide Receptors metabolism
Lymphocyte Activation
Mucosal-Associated Invariant T Cells metabolism
Mucosal-Associated Invariant T Cells microbiology
Receptors, Antigen, T-Cell genetics
Receptors, Antigen, T-Cell metabolism
Transcriptome
HIV Infections immunology
Mucosal-Associated Invariant T Cells immunology
Viremia immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 31937782
- Full Text :
- https://doi.org/10.1038/s41467-019-13975-9