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Diagnosis of severe community-acquired pneumonia caused by Acinetobacter baumannii through next-generation sequencing: a case report.
- Source :
-
BMC infectious diseases [BMC Infect Dis] 2020 Jan 15; Vol. 20 (1), pp. 45. Date of Electronic Publication: 2020 Jan 15. - Publication Year :
- 2020
-
Abstract
- Background: Acinetobacter baumannii is a gram-negative aerobic bacillus that is commonly causes of hospital-acquired infections. Community-acquired pneumonia caused by Acinetobacter baumannii (CAP-Ab) is rare but fatal if diagnosis and treatment are delayed. Conventional culture of clinical specimens is the main method for clinical diagnosis of A. baumannii infections which may suffer from limited positive rate and is time consuming. Timely and precise diagnosis of CAP-Ab remains challenging.<br />Case Presentation: A 66-year-old man with 24 h history of acute fever and dyspnea was admitted to our hospital. He was diagnosed as severe community acquired pneumonia (CAP), septic shock, respiratory failure and acute kidney injury. Next-generation sequencing (NGS) was performed on the patient's sputum and blood, which identified numerous A. baumannii nucleotide sequences in the sample of sputum and led to the rapid diagnosis and treatment of community acquired pneumonia caused by A. baumannii. This result was confirmed by subsequent sputum culture.<br />Conclusions: This case described that the successful application of the next generation sequencing assisting the speedy diagnosis of A. baumannii infection provides a new idea for the timely diagnosis of CAP-Ab and highlights that NGS is a promising tool in rapid etiological diagnosis of acute and severe infectious diseases.
- Subjects :
- Acinetobacter Infections drug therapy
Acinetobacter Infections microbiology
Acute Kidney Injury complications
Aged
Anti-Bacterial Agents therapeutic use
China
Community-Acquired Infections blood
Community-Acquired Infections drug therapy
Cross Infection
Dyspnea complications
Fever complications
Hospitalization
Humans
Male
Microbial Sensitivity Tests
Pneumonia, Bacterial blood
Pneumonia, Bacterial drug therapy
Respiratory Insufficiency complications
Shock, Septic complications
Sputum microbiology
Treatment Outcome
Acinetobacter Infections diagnosis
Acinetobacter baumannii genetics
Community-Acquired Infections diagnosis
High-Throughput Nucleotide Sequencing
Pneumonia, Bacterial diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2334
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 31941459
- Full Text :
- https://doi.org/10.1186/s12879-019-4733-5