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Is kidney function associated with primary open-angle glaucoma? Findings from the Asian Eye Epidemiology Consortium.
- Source :
-
The British journal of ophthalmology [Br J Ophthalmol] 2020 Sep; Vol. 104 (9), pp. 1298-1303. Date of Electronic Publication: 2020 Jan 20. - Publication Year :
- 2020
-
Abstract
- Aim: To comprehensively examine the association between kidney function and primary open angle glaucoma (POAG) in a large consortium of multiple Asian population-based studies.<br />Methods: 28 925 participants (57 340 eyes) from 9 population-based studies (from China, Hong Kong, India, Korea, Russia, Singapore) of the Asian Eye Epidemiology Consortium were included. Across all studies, POAG was defined based on the International Society of Geographical and Epidemiological Ophthalmology criteria. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine. Chronic kidney disease (CKD) was defined as eGFR<60 mL/min/1.73 m <superscript>2</superscript> . Eye-specific data were pooled from each study. Multivariable regression analysis with generalised estimating equation models was performed to evaluate the associations between kidney function with POAG and intraocular pressure (IOP).<br />Results: After adjusting for age, gender, study group, hypertension, diabetes, hyperlipidaemia, body mass index, smoking status and IOP, lower eGFR (per 10 mL/min/1.73 m <superscript>2</superscript> decrease) was not significantly associated with POAG (OR=1.01; p=0.77). Presence of CKD was also not significantly associated with POAG (OR=1.01; p=0.739). Furthermore, lower eGFR and presence of CKD were not associated with IOP (all p≥0.12), However, in the subgroup of combined Korean and Chinese individuals, significant associations between lower eGFR (OR=1.09; 95% CI 1.00 to 1.18; p=0.048) and severe kidney function decline (<45 mL/min/1.73 m <superscript>2</superscript> ; OR=2.57; 95% CI 1.34 to 4.93; p=0.004) with POAG, were observed.<br />Conclusion: In this large pooled-analysis of multiple Asian population-based studies, our findings suggest that the association between CKD and POAG may only be present in East Asians specifically but not in the overall Asian population. Further evaluation in Japanese population is warranted to confirm this observation.<br />Competing Interests: Competing interests: None declared.<br /> (© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.)
- Subjects :
- Adult
Aged
Asia epidemiology
Asian People statistics & numerical data
Cross-Sectional Studies
Epidemiologic Studies
Female
Glaucoma, Open-Angle epidemiology
Glomerular Filtration Rate
Humans
Intraocular Pressure physiology
Male
Middle Aged
Renal Insufficiency, Chronic epidemiology
Renal Insufficiency, Chronic physiopathology
Tonometry, Ocular
Visual Field Tests
Visual Fields physiology
Glaucoma, Open-Angle physiopathology
Kidney physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1468-2079
- Volume :
- 104
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The British journal of ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 31959588
- Full Text :
- https://doi.org/10.1136/bjophthalmol-2019-314890