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Heart rate variability as an independent predictor for 8-year mortality among chronic hemodialysis patients.

Heart rate variability as an independent predictor for 8-year mortality among chronic hemodialysis patients.

Authors :
Chang YM
Huang YT
Chen IL
Yang CL
Leu SC
Su HL
Kao JL
Tsai SC
Jhen RN
Shiao CC
Source :
Scientific reports [Sci Rep] 2020 Jan 21; Vol. 10 (1), pp. 881. Date of Electronic Publication: 2020 Jan 21.
Publication Year :
2020

Abstract

The repeated measurements of heart rate variability (HRV) is more relevant than a single HRV measurement in predicting patient prognosis but is less addressed previously. This prospective study aimed to investigate the association between repeated measurements of HRV and long-term mortality in chronic hemodialysis patients. The 164 patients (65.0 ± 13.1 years; woman, 57.3%) were enrolled from June 1, 2010, to August 31, 2010, and received four HRV measurements (before and during the index hemodialysis session) after the enrollment. The baseline characteristic and clinical variables, including mortality, were documented. The joint modeling method and Cox regression were used for statistical analyses. After an 8-year follow-up, 79 patients expired, and 85 patients survived. We found that higher normalized high-frequency (nHF) (hazard ratio [HR] 1.033) as well as lower very-low-frequency (HR 0.990), Variance (HR 0.991), normalized low-frequency (HR 0.999, P = 0.006), and low-frequency/high-frequency ratio (HR 0.796) were independent predictors for cardiovascular mortality. Whereas the independent predictors for infection-associated mortality included higher nHF (HR 1.033) as well as higher age (HR 19.29) and lower serum albumin (HR 0.01, P = 0.001). (all P < 0.001 unless otherwise stated) In conclusion, HRV measurement predicts long-term mortality among hemodialysis patients.

Details

Language :
English
ISSN :
2045-2322
Volume :
10
Issue :
1
Database :
MEDLINE
Journal :
Scientific reports
Publication Type :
Academic Journal
Accession number :
31964940
Full Text :
https://doi.org/10.1038/s41598-020-57792-3