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Lorcaserin maintenance fails to attenuate heroin vs. food choice in rhesus monkeys.

Authors :
Townsend EA
Negus SS
Poklis JL
Banks ML
Source :
Drug and alcohol dependence [Drug Alcohol Depend] 2020 Mar 01; Vol. 208, pp. 107848. Date of Electronic Publication: 2020 Jan 17.
Publication Year :
2020

Abstract

Background: The current opioid crisis has reinvigorated preclinical research in the evaluation of non-opioid candidate treatments for opioid use disorder (OUD). Emerging evidence suggests 5-HT <subscript>2C</subscript> receptor agonists may attenuate the abuse-related effects of opioids. This study evaluated effectiveness of 7-day treatment with the clinically available 5-HT <subscript>2C</subscript> agonist lorcaserin (Belviq®) on heroin-vs.-food choice in rhesus monkeys. Lorcaserin effects were compared to effects produced by 7-day saline substitution and by 7-day treatment with the opioid antagonist naltrexone.<br />Methods: Adult male (1) and female (6) rhesus monkeys were trained to respond under a concurrent schedule of food delivery (1 g pellets, fixed-ratio 100 schedule) and intravenous heroin injections (0-0.032 mg/kg/injection, fixed-ratio 10 schedule) during daily 2 h sessions. Heroin choice dose-effect functions were determined daily before and following 7-day saline substitution or 7-day continuous treatment with naltrexone (0.0032-0.032 mg/kg/h, IV) or lorcaserin (0.032-0.32 mg/kg/h, IV).<br />Results: Under baseline conditions, increasing heroin doses maintained a dose-dependent increase in heroin choice. Both saline substitution and 7-day naltrexone treatment significantly attenuated heroin choice and produced a reciprocal increase in food choice. Continuous lorcaserin (0.32 mg/kg/h) treatment significantly increased heroin choice.<br />Conclusions: In contrast to saline substitution and naltrexone, lorcaserin treatment was ineffective to reduce heroin-vs.-food choice. These preclinical results do not support the therapeutic potential and continued evaluation of lorcaserin as a candidate OUD treatment.<br />Competing Interests: Declaration of Competing Interest All authors declare there are no competing financial interests or potential conflicts of interest in relation to the research described.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1879-0046
Volume :
208
Database :
MEDLINE
Journal :
Drug and alcohol dependence
Publication Type :
Academic Journal
Accession number :
31982193
Full Text :
https://doi.org/10.1016/j.drugalcdep.2020.107848