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pH-Triggered geometrical shape switching of a cationic peptide nanoparticle for cellular uptake and drug delivery.
- Source :
-
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2020 Apr; Vol. 188, pp. 110811. Date of Electronic Publication: 2020 Jan 18. - Publication Year :
- 2020
-
Abstract
- The geometry of nanoparticles plays an important role in their performance as drug carriers. However, the pH-triggered geometrical shape switching of a cationic peptide consisting of isoleucine and lysine is seldom reported. In this work, we designed a cationic peptide with acid reactivity that can be loaded with the poorly soluble antitumor drug (doxorubicin (DOX)) to enhance tumor cell uptake and drug delivery. In a weakly acidic environment, a large portion of random coil structures formed, which subsequently led to nanoparticle destruction and rapid DOX release. In vitro studies demonstrated that this cationic peptide exhibits low toxicity to normal cells. The amount of DOX-encapsulating peptide nanoparticles taken up by tumor cells was greater than that taken up by normal cells. Our results indicated that the use of a weakly acidic microenvironment to induce geometric shape switching in drug-loaded peptide nanoparticles should be a promising strategy for antitumor drug delivery.<br />Competing Interests: Declaration of Competing Interest The authors declare no competing financial interest.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Antibiotics, Antineoplastic chemistry
Antimicrobial Cationic Peptides chemical synthesis
Cell Line, Tumor
Cell Proliferation drug effects
Cell Survival drug effects
Doxorubicin chemistry
Drug Screening Assays, Antitumor
Humans
Hydrogen-Ion Concentration
Particle Size
Surface Properties
Antibiotics, Antineoplastic pharmacology
Antimicrobial Cationic Peptides chemistry
Doxorubicin pharmacology
Drug Delivery Systems
Nanoparticles chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4367
- Volume :
- 188
- Database :
- MEDLINE
- Journal :
- Colloids and surfaces. B, Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 31982793
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2020.110811