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A Cross-sectional Study of Group B Streptococcus-Associated Sepsis, Coinfections, and Antibiotic Susceptibility Profile in Neonates in Pakistan.
- Source :
-
Advances in neonatal care : official journal of the National Association of Neonatal Nurses [Adv Neonatal Care] 2020 Aug; Vol. 20 (4), pp. E59-E69. - Publication Year :
- 2020
-
Abstract
- Background: Neonatal sepsis is a leading cause of morbidity and early-life mortality worldwide, and previous data have reported the highest neonatal mortality rate in Pakistan.<br />Purpose: The present study aimed to decipher the prevalence of group B Streptococcus (GBS)-associated sepsis, coinfections, and antibiotic susceptibility of isolated microbes in neonates.<br />Methods: Blood samples of 100 cases of neonatal sepsis were subcultured on blood agar, GBS agar, and MacConkey agar for isolation of GBS and suspected microbes.<br />Results: Of 100 neonatal blood samples, 85 blood samples were culture-positive, including mixed culture growth (n = 18), 25 samples as early-onset neonatal sepsis (EONS) and 60 as late-onset neonatal sepsis (LONS). Staphylococcus aureus showed high percent positivity (31.4%), followed by Candida sp (16.5%), GBS (14.1%), Klebsiella (14.1%), Staphylococcus epidermidis (11.8%), Pseudomonas (9.4%), Acinetobacter (9.4%), Esherichia coli (8.2%), and Enterococcus (5.9%). GBS was isolated more frequently from EONS than from LONS with 50% coinfections. Mode of delivery, gender, and respiratory distress in neonates were significantly associated with culture-positive sepsis. GBS isolates were highly (91.7%) susceptible to vancomycin, cefotaxime, and chloramphenicol, followed by penicillin (83.3%), ampicillin, and tetracycline (75%). GBS isolates were resistant to erythromycin, clindamycin, ciprofloxacin, and linezolid.<br />Implications for Practice: Our findings evidenced GBS-associated risk factors and antibiotic susceptibility pattern of neonatal sepsis, which will help clinicians in management, control, and treatment of neonatal sepsis.<br />Implications for Research: The epidemiological evidence of GBS-associated neonatal sepsis, demographic characteristics, risk factor data analysis, and drug resistance pattern has disease prevention implications in neonates in low-income countries including Pakistan.
- Subjects :
- Coinfection drug therapy
Coinfection microbiology
Cross-Sectional Studies
Humans
Infant, Newborn
Pakistan epidemiology
Risk Factors
Streptococcal Infections microbiology
Streptococcus agalactiae drug effects
Anti-Bacterial Agents pharmacology
Neonatal Sepsis drug therapy
Neonatal Sepsis epidemiology
Neonatal Sepsis microbiology
Streptococcal Infections drug therapy
Streptococcal Infections epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1536-0911
- Volume :
- 20
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Advances in neonatal care : official journal of the National Association of Neonatal Nurses
- Publication Type :
- Academic Journal
- Accession number :
- 31996563
- Full Text :
- https://doi.org/10.1097/ANC.0000000000000701