Neonatal Acute Liver Failure.

Authors :: Larson-Nath C
Vitola BE
Source :: Clinics in perinatology [Clin Perinatol] 2020 Mar; Vol. 47 (1), pp. 25-39. Date of Electronic Publication: 2019 Oct 17.
Publication Year :: 2020
Abstract: Neonatal acute liver failure (NALF) is a rare disease with a few known primary causes: gestational alloimmune liver disease (GALD), viral infections, metabolic diseases, and ischemic injury. Many cases still do not have a known cause. Laboratory evaluation may suggest a diagnosis. Most of the known causes have disease-specific treatments that improve outcomes. Survival is improving with better knowledge about and treatment options for GALD; however, overall mortality for NALF is still 24%. Liver transplant remains an important option for neonates with an indeterminate cause of NALF and those who do not respond to established treatments.<br />Competing Interests: Disclosure The authors have nothing to disclose.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)