The Pharmacopea within Triatomine Salivary Glands.

Authors :: Santiago PB
de Araújo CN
Charneau S
Praça YR
Bastos IMD
Ribeiro JMC
Santana JM
Source :: Trends in parasitology [Trends Parasitol] 2020 Mar; Vol. 36 (3), pp. 250-265. Date of Electronic Publication: 2020 Jan 29.
Publication Year :: 2020
Abstract: Triatomines are blood-feeding insects that prey on vertebrate hosts. Their saliva is largely responsible for their feeding success. The triatomine salivary content has been studied over the past decades, revealing multifunctional bioactive proteins targeting the host´s hemostasis and immune system. Recently, sequencing of salivary-gland mRNA libraries revealed increasingly complex and complete transcript databases that have been used to validate the expression of deduced proteins through proteomics. This review provides an insight into the journey of discovery and characterization of novel molecules in triatomine saliva.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)