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Potential Antidiabetic Activity of Extracts and Isolated Compound from Adenosma bracteosum (Bonati).
- Source :
-
Biomolecules [Biomolecules] 2020 Jan 29; Vol. 10 (2). Date of Electronic Publication: 2020 Jan 29. - Publication Year :
- 2020
-
Abstract
- Adenosma bracteosum Bonati. ( A. bracteosum ) has been used in traditional and modern medicine in Vietnam for curing hepatitis. In this study, ethanol and aqueous extracts of A. bracteosum were evaluated for their α-glucosidase inhibitory activities and anti-hyperglycemic effects on glucose loaded hyperglycemic and streptozotocin (STZ) induced diabetic mice. The α-glucosidase inhibition of the extracts was evaluated by colorimetric assays, and the anti-diabetic activity was tested on a STZ-induced diabetic mice model. The ethanol and aqueous extracts showed a significant α-glucosidase inhibitory activity, which was more effective than acarbose at the same concentration. In the STZ-induced diabetic mice, both extracts showed a strong anti-hyperglycemic activity, with the group receiving 50 mg/kg of ethanol extract and the group receiving 50 mg/kg of aqueous extract presenting 64.42% and 57.69% reductions, respectively, in the blood glucose levels when compared with the diabetic control group, on day 21 ( p > 0.05 ). Isoscutellarein-8-O-β-D-glucopyranoside (IG) was identified from the ethanol extract, which showed a strong inhibitory activity against α-glucosidase, with a ten times higher potency compared with the positive control acarbose. The anti-hyperglycemic effect of IG was effectively similar to the standard drug, glibenclamide, at the same dose of 10 mg/kg ( p > 0.05 ). These results indicated that A. bracteosum has a great antidiabetic potential.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Acarbose pharmacology
Animals
Biphenyl Compounds chemistry
Blood Glucose analysis
Body Weight
Ethanol chemistry
Female
Flavonoids pharmacology
Free Radical Scavengers pharmacology
Glucose Tolerance Test
Glycoside Hydrolase Inhibitors pharmacology
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Male
Mice
Phytochemicals pharmacology
Picrates chemistry
Vietnam
alpha-Glucosidases metabolism
alpha-Glucosidases pharmacology
Diabetes Mellitus, Experimental drug therapy
Hypoglycemic Agents pharmacology
Magnoliopsida chemistry
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2218-273X
- Volume :
- 10
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biomolecules
- Publication Type :
- Academic Journal
- Accession number :
- 32013271
- Full Text :
- https://doi.org/10.3390/biom10020201