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Elevated antistreptolysin O titer is closely related to cardiac mitral insufficiency in untreated patients with Takayasu arteritis.
- Source :
-
BMC cardiovascular disorders [BMC Cardiovasc Disord] 2020 Feb 03; Vol. 20 (1), pp. 52. Date of Electronic Publication: 2020 Feb 03. - Publication Year :
- 2020
-
Abstract
- Background: The etiology of Takayasu arteritis (TA) is unknown; however, a possible relationship between streptococcal infection and TA has been proposed. This study aimed to identify the clinical features and cardiac valvular involvement in untreated TA patients with an elevated antistreptolysin O (ASO) titer.<br />Methods: In this retrospective study, the clinical characteristics and features of valvular involvement were compared in TA patients with or without an elevated ASO titer.<br />Results: Of the 74 untreated TA patients, 13 patients were found have elevated ASO titers (17.6%). Mitral insufficiency was the most common in patients with elevated ASO (69.2%, 9/13), followed by aortic valve insufficiency (46.2%, 5/13) and tricuspid insufficiency (46.2%, 5/13), which were no significantly different than that in normal ASO group. The proportions of moderate to severe mitral (30.8% vs 1.6%, p = 0.000) and tricuspid valve (15.4% vs 1.64%, p = 0.023) insufficiency in the ASO positive group were significantly higher than those in the ASO negative group. The odds of mitral regurgitation in patients with elevated ASO titers were 3.9 times higher than those in the group with normal ASO titers (p = 0.053, OR = 3.929, 95% confidence interval [CI]: 0.983-15.694). Furthermore, the risk of moderate to severe mitral insufficiency in patients with elevated ASO titers was 41.6 times higher than that in patients with normal ASO titers (p = 0.002, OR = 41.600, 95% CI: 3.867-447.559).<br />Conclusions: An increase in ASO titer is related to valvular involvement in TA and is closely linked to mitral insufficiency.
- Subjects :
- Adult
Biomarkers blood
Female
Humans
Male
Middle Aged
Mitral Valve Insufficiency diagnostic imaging
Mitral Valve Insufficiency etiology
Retrospective Studies
Risk Factors
Takayasu Arteritis complications
Takayasu Arteritis diagnosis
Up-Regulation
Young Adult
Antistreptolysin blood
Mitral Valve Insufficiency blood
Takayasu Arteritis blood
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2261
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC cardiovascular disorders
- Publication Type :
- Academic Journal
- Accession number :
- 32013899
- Full Text :
- https://doi.org/10.1186/s12872-020-01364-w