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Predictive factors for the development of proteinuria in cancer patients treated with bevacizumab, ramucirumab, and aflibercept: a single-institution retrospective analysis.
- Source :
-
Scientific reports [Sci Rep] 2020 Feb 06; Vol. 10 (1), pp. 2011. Date of Electronic Publication: 2020 Feb 06. - Publication Year :
- 2020
-
Abstract
- The development of proteinuria restricts the dose of anti-angiogenic agents, thereby reducing their efficacy. Thus, this retrospective study was undertaken to identify predictive factors of the development of angiogenesis inhibitor-induced proteinuria, and to elucidate if there is a difference in the likelihood of proteinuria among anti-angiogenic agents or cancer types, to help guide future strategies to improve the safety, efficacy, and quality of life of patients receiving chemotherapy. Between April 2014 and February 2019, 124 cancer patients at our outpatient chemotherapy center who were receiving chemotherapy with bevacizumab, ramucirumab, or aflibercept were enrolled. Variables related to the development of proteinuria were extracted from the patients' clinical records and used for regression analysis. The level of the proteinuria was evaluated based on CTCAE version 5. Multivariate ordered logistic regression analysis was performed to identify predictive factors for the development of proteinuria. The Wilcoxon/Kruskal-Wallis test was used to identify significant differences between groups. Significant factors identified included systolic blood pressure (SBP) [odds ratio (OR) = 1.031, 95% confidence interval (CI) = 1.005-1.058; P = 0.0197], number of cycles (OR = 1.049, 95% CI = 1.018-1.082; P = 0.0019), and calcium channel blocker use (OR = 2.589, 95% CI = 1.090-6.146; P = 0.0311). There was no difference among the three anti-angiogenic agents (P = 0.4969) or among cancer types (P = 0.2726) in the likelihood of proteinuria. In conclusion, SBP, number of cycles, and calcium channel blocker use were identified as significant predictors of the development of angiogenesis inhibitor-induced proteinuria. There was no difference among the three anti-angiogenic agents or among cancer types.
- Subjects :
- Adult
Aged
Aged, 80 and over
Angiogenesis Inhibitors administration & dosage
Antibodies, Monoclonal, Humanized administration & dosage
Antibodies, Monoclonal, Humanized adverse effects
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Bevacizumab administration & dosage
Bevacizumab adverse effects
Blood Pressure physiology
Calcium Channel Blockers adverse effects
Dose-Response Relationship, Drug
Female
Humans
Male
Middle Aged
Proteinuria chemically induced
Proteinuria physiopathology
Quality of Life
Receptors, Vascular Endothelial Growth Factor administration & dosage
Recombinant Fusion Proteins administration & dosage
Recombinant Fusion Proteins adverse effects
Retrospective Studies
Risk Assessment
Risk Factors
Ramucirumab
Angiogenesis Inhibitors adverse effects
Antineoplastic Combined Chemotherapy Protocols adverse effects
Neoplasms drug therapy
Proteinuria epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 32029849
- Full Text :
- https://doi.org/10.1038/s41598-020-58994-5