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Enzyme-free amplified SERS immunoassay for the ultrasensitive detection of disease biomarkers.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Mar 05; Vol. 56 (19), pp. 2933-2936. - Publication Year :
- 2020
-
Abstract
- We developed a novel enzyme-free amplified SERS immunoassay by combining silver nanoparticle (AgNP)-linked immunoreaction and SERS transduction for the detection of disease biomarkers. As a proof of concept, our method was successfully illustrated with the disease biomarker α-fetoprotein with the detection limit of 3.3 × 10-13 g mL-1 and a double-blind experiment consisting of tens of serum samples was performed to confirm its reliability.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 56
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 32040106
- Full Text :
- https://doi.org/10.1039/c9cc09379f