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Enzymatic synthesis and biological characterization of a novel mangiferin glucoside.
- Source :
-
Enzyme and microbial technology [Enzyme Microb Technol] 2020 Mar; Vol. 134, pp. 109479. Date of Electronic Publication: 2019 Nov 23. - Publication Year :
- 2020
-
Abstract
- Mangiferin, a major constituent of Mangifera indica L., has attracted substantial attention due to its anti-oxidant, anti-diabetic, anti-inflammatory, and anti-microbial activities. However, its poor solubility in water limits its use in food and pharmaceutical industries. In this study, novel mangiferin-(1→6)-α-d-glucopyranoside (Mg-G1) was enzymatically synthesized from mangiferin and sucrose using glucansucrase from Leuconostoc mesenteroides B-512F/KM, and optimized using response surface methodology. The water solubility of Mg-G1 was found to be 824.7 mM, which is more than 2300-fold higher than that of mangiferin. Mg-G1 also showed DPPH radical scavenging activity and superoxide dismutase (SOD)-like scavenging activity, which were 4.77- and 3.71-fold higher than that of mangiferin, respectively. Mg-G1 displayed inhibitory activity against human intestinal maltase and COX-2. Thus, the novel glucosylated mangiferin may be used as an ingredient in functional food and pharmaceutical application.<br />Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Antioxidants metabolism
Cyclooxygenase 2 Inhibitors metabolism
Humans
Solubility
Sucrose metabolism
Superoxide Dismutase metabolism
alpha-Glucosidases metabolism
Glucosides biosynthesis
Glycosyltransferases metabolism
Leuconostoc mesenteroides enzymology
Mangifera chemistry
Xanthones metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0909
- Volume :
- 134
- Database :
- MEDLINE
- Journal :
- Enzyme and microbial technology
- Publication Type :
- Academic Journal
- Accession number :
- 32044026
- Full Text :
- https://doi.org/10.1016/j.enzmictec.2019.109479