Back to Search
Start Over
Transmission of X-linked Ovarian Cancer: Characterization and Implications.
- Source :
-
Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2020 Feb 07; Vol. 10 (2). Date of Electronic Publication: 2020 Feb 07. - Publication Year :
- 2020
-
Abstract
- We recently reported evidence that a strong, BRCA-independent locus on the X-chromosome may contribute to ovarian cancer predisposition in families ascertained from the Familial Ovarian Cancer Registry (Buffalo, NY, USA). While it has been estimated that approximately 20% of all ovarian cancer cases are hereditary, it is possible that a significant proportion of cases previously believed to be sporadic may, in fact, be X-linked. Such X-linked disease has a distinct pattern; it implies that a father will necessarily pass a risk allele to each of his daughters, increasing the prevalence of cancers clustered within a family. X-chromosome inactivation further influences the expression of X-linked alleles and may represent a novel target for screening and therapy. Herein, we review the current literature regarding X-linked ovarian cancer and interpret allele transmission-based models to characterize X-linked ovarian cancer and develop a framework for clinical and epidemiological familial ascertainment to inform the design of future studies.<br />Competing Interests: The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
Details
- Language :
- English
- ISSN :
- 2075-4418
- Volume :
- 10
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Diagnostics (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 32046210
- Full Text :
- https://doi.org/10.3390/diagnostics10020090