Extracellular vesicles from myelodysplastic mesenchymal stromal cells induce DNA damage and mutagenesis of hematopoietic stem cells through miRNA transfer.

Authors :: Meunier M
Guttin A
Ancelet S
Laurin D
Zannoni J
Lefebvre C
Tondeur S
Persoons V
Pezet M
Pernet-Gallay K
Chuffart F
Rousseaux S
Testard Q
Thevenon J
Jouzier C
Deleuze JF
Laulagnier K
Sadoul R
Chatellard C
Hainaut P
Polack B
Cahn JY
Issartel JP
Park S
Source :: Leukemia [Leukemia] 2020 Aug; Vol. 34 (8), pp. 2249-2253. Date of Electronic Publication: 2020 Feb 12.
Publication Year :: 2020

Subjects :: DEAD-box RNA Helicases genetics
Humans
MicroRNAs
Myelodysplastic Syndromes etiology
Myelodysplastic Syndromes genetics
Ribonuclease III genetics
DNA Damage
Extracellular Vesicles physiology
Hematopoietic Stem Cells metabolism
Mesenchymal Stem Cells physiology
Mutagenesis
Myelodysplastic Syndromes pathology

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