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T Lymphocyte Subsets Associated With Prevalent Diabetes in Veterans With and Without Human Immunodeficiency Virus.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2020 Jun 29; Vol. 222 (2), pp. 252-262. - Publication Year :
- 2020
-
Abstract
- Background: A higher proportion of circulating memory CD4+ T cells is associated with prevalent diabetes mellitus in the general population. Given the broad changes in adaptive immunity, including memory T-cell expansion, and rising prevalence of diabetes in the human immunodeficiency virus (HIV) population, we assessed whether similar relationships were present in persons with HIV (PWH).<br />Methods: Multiple CD4+ and CD8+ T-cell subsets were measured by flow cytometry, and prevalent diabetes cases were adjudicated by 2 physicians for PWH and HIV-negative participants in the Veterans Aging Cohort Study. Multivariable logistic regression models evaluated the association of T-cell subsets and diabetes stratified by HIV status, adjusted for cytomegalovirus serostatus and traditional risk factors.<br />Results: Among 2385 participants (65% PWH, 95% male, 68% African American), higher CD45RO+ memory CD4+ T cells and lower CD38+ CD4+ T cells were associated with prevalent diabetes, and had a similar effect size, in both the PWH and HIV-negative (Pā ā¤ā .05 for all). Lower CD38+CD8+ T cells were also associated with diabetes in both groups.<br />Conclusions: The CD4+ and CD8+ T-cell subsets associated with diabetes are similar in PWH and HIV-negative individuals, suggesting that diabetes in PWH may be related to chronic immune activation.<br /> (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
- Subjects :
- Biomarkers blood
CD4 Lymphocyte Count
CD8-Positive T-Lymphocytes immunology
Cohort Studies
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Regression Analysis
Veterans
CD4-Positive T-Lymphocytes immunology
Diabetes Complications
Diabetes Mellitus immunology
HIV Infections complications
HIV Infections immunology
Immunologic Memory
T-Lymphocyte Subsets immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 222
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 32052044
- Full Text :
- https://doi.org/10.1093/infdis/jiaa069