Genomic Characterization of Neisseria gonorrhoeae Strains from 2016 U.S. Sentinel Surveillance Displaying Reduced Susceptibility to Azithromycin.

Authors :: Schmerer MW
Abrams AJ
Seby S
Thomas JC 4th
Cartee J
Lucking S
Vidyaprakash E
Pham CD
Sharpe S
Pettus K
St Cyr SB
Torrone EA
Kersh EN
Gernert KM
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Apr 21; Vol. 64 (5). Date of Electronic Publication: 2020 Apr 21 (Print Publication: 2020).
Publication Year :: 2020
Abstract: In 2016, the proportion of Neisseria gonorrhoeae isolates with reduced susceptibility to azithromycin rose to 3.6%. A phylogenetic analysis of 334 N. gonorrhoeae isolates collected in 2016 revealed a single, geographically diverse lineage of isolates with MICs of 2 to 16 μg/ml that carried a mosaic-like mtr locus, whereas the majority of isolates with MICs of ≥16 μg/ml appeared sporadically and carried 23S rRNA mutations. Continued molecular surveillance of N. gonorrhoeae isolates will identify new resistance mechanisms.<br /> (Copyright © 2020 American Society for Microbiology.)

Subjects :: Alleles
Genetic Loci genetics
Gonorrhea epidemiology
Gonorrhea microbiology
Humans
Microbial Sensitivity Tests
Molecular Epidemiology
RNA, Ribosomal, 23S genetics
United States epidemiology
Anti-Bacterial Agents pharmacology
Azithromycin pharmacology
Drug Resistance, Bacterial genetics
Neisseria gonorrhoeae drug effects
Neisseria gonorrhoeae genetics
Sentinel Surveillance

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