Effect of TRF 1 rs3863242 polymorphism on telomere length in omethoate-exposed workers.

Telomere length was found to be associated with omethoate exposure and polymorphisms in certain genes among occupational workers. However, whether the polymorphisms in telomere-binding protein genes influence telomere length remains unclear. To explore the correlation between telomere length and polymorphisms in telomere-binding protein genes, telomere length in peripheral blood leukocytes was determined by real-time quantitative polymerase chain reaction in 180 omethoate-exposed workers and 115 healthy controls. Polymorphisms in 10 pairs of alleles were detected using flight mass spectrometry or polymerase chain reaction-restriction fragment length polymorphism technique. The results showed that individuals with GG genotype in TRF 1 rs3863242 had longer telomere lengths than those with AG + AA genotype in the control group ( p  = 0.005). The multiple regression analysis suggested that both omethoate exposure ( b  = 0.526, p  < 0.001) and TRF 1 rs3863242 GG ( b  = 0.220, p  = 0.002) were related to a longer telomere length. In conclusion, GG genotype in TRF 1 rs3863242 is linked to prolongation of telomere length, and individuals with GG genotype are recommended to strengthen health protection in a Chinese occupational omethoate-exposed population.