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Zipcode Binding Protein 1 (ZBP1; IGF2BP1): A Model for Sequence-Specific RNA Regulation.
- Source :
-
Cold Spring Harbor symposia on quantitative biology [Cold Spring Harb Symp Quant Biol] 2019; Vol. 84, pp. 1-10. Date of Electronic Publication: 2020 Feb 21. - Publication Year :
- 2019
-
Abstract
- The fate of an RNA, from its localization, translation, and ultimate decay, is dictated by interactions with RNA binding proteins (RBPs). β-actin mRNA has functioned as the classic example of RNA localization in eukaryotic cells. Studies of β-actin mRNA over the past three decades have allowed understanding of how RBPs, such as ZBP1 (IGF2BP1), can control both RNA localization and translational status. Here, we summarize studies of β-actin mRNA and focus on how ZBP1 serves as a model for understanding interactions between RNA and their binding protein(s). Central to the study of RNA and RBPs were technological developments that occurred along the way. We conclude with a future outlook highlighting new technologies that may be used to address still unanswered questions about RBP-mediated regulation of mRNA during its life cycle, within the cell.<br /> (© 2019 Biswas et al.; Published by Cold Spring Harbor Laboratory Press.)
Details
- Language :
- English
- ISSN :
- 1943-4456
- Volume :
- 84
- Database :
- MEDLINE
- Journal :
- Cold Spring Harbor symposia on quantitative biology
- Publication Type :
- Academic Journal
- Accession number :
- 32086331
- Full Text :
- https://doi.org/10.1101/sqb.2019.84.039396