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Physical and biological properties of alginate/carbon nanofibers hydrogel films.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2020 May 15; Vol. 151, pp. 499-507. Date of Electronic Publication: 2020 Feb 20. - Publication Year :
- 2020
-
Abstract
- Alginates are renewable materials with excellent biocompatibility and cost-effectiveness in comparison with other biodegradable polymers. However, these hydrogels have poor mechanical properties that restrict their applications in biomedical fields such as skin tissue engineering. In this regard, the study follows an enhanced engineering route to produce alginate-based films reinforced with different amounts (0, 0.1, 0.5, 1 and 2% w/w) of carbon nanofibers (CNFs) and characterize their physical and biological properties. The results of this study showed that these composites possess similar biological properties to neat alginate hydrogels. Thus, none of the synthesized composite materials were cytotoxic and no cell adhesion was observed on the films. Water sorption at the body temperature did not suffer strong changes with the incorporation of CNFs into the alginate matrix. The dynamic mechanical and tensile/compressive properties of calcium alginate significantly improved with the addition of even a very low amount of CNFs. Thus, the tensile and compression modulus of the calcium alginate films in the dry and hydrated state increases up to three and six times, respectively, with the addition of 2% w/w CNFs. In addition, the composites reinforced with the lowest CNFs content have the advantage of possessing more transparency and lower production costs.<br />Competing Interests: Declaration of competing interest The authors declare no conflict of interest.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Biocompatible Materials chemistry
Biocompatible Materials pharmacology
Biopolymers chemistry
Cell Survival
Chemical Phenomena
Humans
Mechanical Phenomena
Nanocomposites chemistry
Nanofibers ultrastructure
Temperature
Alginates chemistry
Carbon chemistry
Methylgalactosides chemistry
Nanofibers chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 151
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 32088232
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2020.02.213