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Chrysin attenuates traumatic brain injury-induced recognition memory decline, and anxiety/depression-like behaviors in rats: Insights into underlying mechanisms.
- Source :
-
Psychopharmacology [Psychopharmacology (Berl)] 2020 Jun; Vol. 237 (6), pp. 1607-1619. Date of Electronic Publication: 2020 Feb 22. - Publication Year :
- 2020
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Abstract
- Rationale: Cortical and hippocampal neuronal apoptosis and neuroinflammation are associated with behavioral deficits following traumatic brain injury (TBI).<br />Objectives: The present study was designed to investigate the potential protective effects of flavonoid chrysin against TBI-induced vestibulomotor impairment, exploratory/locomotor dysfunctions, recognition memory decline, and anxiety/depression-like behaviors, as well as the verified possible involved mechanisms.<br />Methods: Chrysin (25, 50, or 100 mg/kg/day; P.O.) was administered to rats immediately after diffuse TBI induction, and it was continued for 3 or 14 days. Behavioral functions were assessed by employing standard behavioral paradigms at scheduled points in time. Three days post-TBI, inflammation status was assayed in both cerebral cortex and hippocampus using ELISA kits. Moreover, apoptosis and expression of Bcl-2 family proteins were examined by TUNEL staining and immunohistochemistry, respectively.<br />Results: The results indicated that treatment with chrysin improved vestibulomotor dysfunction, ameliorated recognition memory deficit, and attenuated anxiety/depression-like behaviors in the rats with TBI. Chrysin treatment also modulated inflammation status, reduced apoptotic index, and regulated Bcl-2 family proteins expression in the brains of rats with TBI.<br />Conclusions: In conclusion, the results suggest that chrysin could be beneficial for protection against TBI-associated behavioral deficits, owing to its anti-apoptotic and anti-inflammatory properties.
- Subjects :
- Animals
Anxiety etiology
Anxiety psychology
Apoptosis drug effects
Apoptosis physiology
Brain drug effects
Brain physiology
Brain Injuries, Traumatic complications
Brain Injuries, Traumatic psychology
Depression etiology
Depression psychology
Flavonoids pharmacology
Male
Memory Disorders etiology
Memory Disorders metabolism
Memory Disorders psychology
Rats
Rats, Wistar
Anxiety drug therapy
Brain Injuries, Traumatic drug therapy
Depression drug therapy
Flavonoids therapeutic use
Memory Disorders drug therapy
Recognition, Psychology drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2072
- Volume :
- 237
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 32088834
- Full Text :
- https://doi.org/10.1007/s00213-020-05482-3