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A Novel One-Day Learning Procedure for Mice.
- Source :
-
Current protocols in mouse biology [Curr Protoc Mouse Biol] 2020 Mar; Vol. 10 (1), pp. e68. - Publication Year :
- 2020
-
Abstract
- Current preclinical cognitive assessments are highly time intensive, with lengthy assessment procedures. In this regard, a single-day assay that focuses just on assessing learning behavior in a time-effective and relatable manner would be of value. This article describes the box maze as a short-term behavioral procedure to measure learning in mice. The protocol consists of allowing mice to explore an enclosed space that has eight holes. One of these holes leads to a tunnel that connects to an escape cage, and the latency to enter this escape hole is recorded for each mouse. Mice are tested four times within a single day, and the decrease in escape latency over time is used as a measure of learning. Age is a factor that affects escape latency in the box maze. Hence, the box-maze procedure is proposed as an efficient test to probe aging and aging intervention-related research questions. © 2020 by John Wiley & Sons, Inc.<br /> (© 2020 John Wiley & Sons, Inc.)
Details
- Language :
- English
- ISSN :
- 2161-2617
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Current protocols in mouse biology
- Publication Type :
- Academic Journal
- Accession number :
- 32096920
- Full Text :
- https://doi.org/10.1002/cpmo.68