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Ferroptosis: Final destination for cancer?
- Source :
-
Cell proliferation [Cell Prolif] 2020 Mar; Vol. 53 (3), pp. e12761. Date of Electronic Publication: 2020 Feb 25. - Publication Year :
- 2020
-
Abstract
- Ferroptosis is a recently defined, non-apoptotic, regulated cell death (RCD) process that comprises abnormal metabolism of cellular lipid oxides catalysed by iron ions or iron-containing enzymes. In this process, a variety of inducers destroy the cell redox balance and produce a large number of lipid peroxidation products, eventually triggering cell death. However, in terms of morphology, biochemistry and genetics, ferroptosis is quite different from apoptosis, necrosis, autophagy-dependent cell death and other RCD processes. A growing number of studies suggest that the relationship between ferroptosis and cancer is extremely complicated and that ferroptosis promises to be a novel approach for the cancer treatment. This article primarily focuses on the mechanism of ferroptosis and discusses the potential application of ferroptosis in cancer therapy.<br /> (© 2020 The Authors. Cell Proliferation published by John Wiley & Sons Ltd.)
- Subjects :
- Animals
Glutathione metabolism
Humans
Iron metabolism
Neoplasms pathology
Neoplasms therapy
Phospholipid Hydroperoxide Glutathione Peroxidase metabolism
Proto-Oncogene Proteins p21(ras) metabolism
Tumor Suppressor Protein p53 metabolism
Ferroptosis
Lipid Peroxidation
Neoplasms metabolism
Peroxides metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2184
- Volume :
- 53
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cell proliferation
- Publication Type :
- Academic Journal
- Accession number :
- 32100402
- Full Text :
- https://doi.org/10.1111/cpr.12761