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Biomarkers of Liver Injury during Transplantation in an Era of Machine Perfusion.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2020 Feb 25; Vol. 21 (5). Date of Electronic Publication: 2020 Feb 25. - Publication Year :
- 2020
-
Abstract
- Liver ischaemia-reperfusion injury (IRI) is an intrinsic part of the transplantation process and damages the parenchymal cells of the liver including hepatocytes, endothelial cells and cholangiocytes. Many biomarkers of IRI have been described over the past two decades that have attempted to quantify the extent of IRI involving different hepatic cellular compartments, with the aim to allow clinicians to predict the suitability of donor livers for transplantation. The advent of machine perfusion has added an additional layer of complexity to this field and has forced researchers to re-evaluate the utility of IRI biomarkers in different machine preservation techniques. In this review, we summarise the current understanding of liver IRI biomarkers and discuss them in the context of machine perfusion.
- Subjects :
- Animals
Biomarkers metabolism
Endothelin-1 metabolism
Fibroblast Growth Factor 2 metabolism
Humans
Interleukins metabolism
Liver Transplantation adverse effects
Liver Transplantation instrumentation
MicroRNAs metabolism
Reperfusion Injury etiology
Reperfusion Injury metabolism
Liver Transplantation methods
Reperfusion Injury diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 21
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 32106626
- Full Text :
- https://doi.org/10.3390/ijms21051578