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Water-dispersible, biocompatible and fluorescent poly(ethylene glycol)-grafted cellulose nanocrystals.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2020 Jun 15; Vol. 153, pp. 46-54. Date of Electronic Publication: 2020 Feb 26. - Publication Year :
- 2020
-
Abstract
- Fluorescent nanoprobe with good water dispersibility was synthesized by the coupling of fluorescent 1,8-naphthalimide dye (NANI) as well as biocompatible poly (ethylene glycol) (PEG) to cellulose nanocrystals (CNC). FTIR, TGA and XPS analysis confirmed the successful covalent conjugation of NANI and PEG. The rod-like morphology of CNC was generally retained after two-step successive grafting of NANI and PEG. The contact angle and transmittance measurements showed that the grafted PEG brushes improve the hydrophilicity of fluorescent CNC probes and their dispersibility in high-concentration NaCl solutions. The fluorescent CNC probe had good biocompatibility and was successfully used for the bioimaging of Hela cells in physiological environment at high salt concentration. Laser confocal microscopy showed that the fluorescent CNC probe can penetrate the cell membrane and disperse uniformly in the cell with good biocompatibility. The fluorescent CNC probe with nanometer size, strong fluorescence emission and high salt-tolerance possess potential application in biomedical field.<br />Competing Interests: Declaration of competing interest The authors declare no competing financial interest.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- HeLa Cells
Humans
Microscopy, Confocal
Cellulose chemistry
Cellulose pharmacokinetics
Cellulose pharmacology
Fluorescent Dyes chemistry
Fluorescent Dyes pharmacokinetics
Fluorescent Dyes pharmacology
Materials Testing
Nanoparticles chemistry
Polyethylene Glycols chemistry
Polyethylene Glycols pharmacokinetics
Polyethylene Glycols pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 153
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 32112832
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2020.02.286