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Preeclampsia before fetal viability in women with primary antiphospholipid syndrome- materno-fetal outcomes in a series of 7 cases.
Preeclampsia before fetal viability in women with primary antiphospholipid syndrome- materno-fetal outcomes in a series of 7 cases.
- Source :
-
Journal of reproductive immunology [J Reprod Immunol] 2020 Apr; Vol. 138, pp. 103101. Date of Electronic Publication: 2020 Feb 22. - Publication Year :
- 2020
-
Abstract
- Introduction: Preeclampsia complicates about 10-17 % of pregnancies with antiphospholipid syndrome (APS). It is often severe and might occur sometimes at early gestation. The development of preeclampsia before fetal viability is a huge challenge for obstetricians and demands an intensive discussion regarding the therapeutical options.<br />Patients and Methods: We retrospectively reviewed the data of 7 women with primary APS who developed preeclampsia before 24 weeks of gestation. Plasma exchange had been performed in four of the cases and two women received corticosteroids. One of the women had received 20 mg of pravastatin daily, starting at 18 weeks of gestation. Neonatal outcome was: live birth in four cases and IUFD in three cases. The main pediatric complications were noted in a 28-week-old premature born boy, who developed severe IRDS and thrombocytopenia. At the present time, the boy continues to have a retarded status.<br />Discussion: This retrospective analysis revealed that women with APS can develop severe preeclampsia even before 20 weeks of gestation. Several management options for prolongation of pregnancy such as plasma exchange, pravastatin, LMHW, hydroxychloroquine/HCQ, or TNF-alpha blocker should be discussed with the patients. Optimal management of preeclampsia before 24 weeks of gestation usually depends on weighing the maternal and fetal complications from expectant management with prolongation of pregnancy versus the predominant fetal and neonatal risks of extreme prematurity from "aggressive" management with immediate delivery.<br />Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Antiphospholipid Syndrome immunology
Antiphospholipid Syndrome therapy
Female
Fetal Viability drug effects
Fetal Viability immunology
Gestational Age
Heparin, Low-Molecular-Weight administration & dosage
Humans
Hydroxychloroquine administration & dosage
Infant, Premature
Plasma Exchange
Pravastatin administration & dosage
Pre-Eclampsia diagnosis
Pre-Eclampsia therapy
Pregnancy
Pregnancy Trimester, First
Pregnancy Trimester, Second
Premature Birth prevention & control
Respiratory Distress Syndrome, Newborn prevention & control
Retrospective Studies
Severity of Illness Index
Time Factors
Antiphospholipid Syndrome complications
Pre-Eclampsia immunology
Premature Birth immunology
Respiratory Distress Syndrome, Newborn immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7603
- Volume :
- 138
- Database :
- MEDLINE
- Journal :
- Journal of reproductive immunology
- Publication Type :
- Academic Journal
- Accession number :
- 32114217
- Full Text :
- https://doi.org/10.1016/j.jri.2020.103101