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The Effect of Dapagliflozin Treatment on Epicardial Adipose Tissue Volume and P-Wave Indices: An Ad-hoc Analysis of The Previous Randomized Clinical Trial.
- Source :
-
Journal of atherosclerosis and thrombosis [J Atheroscler Thromb] 2020 Dec 01; Vol. 27 (12), pp. 1348-1358. Date of Electronic Publication: 2020 Feb 28. - Publication Year :
- 2020
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Abstract
- Aim: Epicardial adipose tissue (EAT) may be associated with arrhythmogenesis. P-wave indices such as P-wave dispersion and P-wave variation indicated a slowed conduction velocity within the atria. This study investigated the effect of dapagliflozin on EAT volume and P-wave indices.<br />Methods: In the present ad hoc analysis, 35 patients with type 2 diabetes mellitus and coronary artery disease were classified into dapagliflozin group (n=18) and conventional treatment group (n=17). At baseline, EAT volume, HbA1c and plasma level of tumor necrotic factor-α (TNF-α) levels, echocardiography, and 12-lead electrocardiogram (ECG) were performed. EAT volume was measured using computed tomography. Using 12-lead ECG, P-wave indices were measured.<br />Results: At baseline, EAT volumes in the dapagliflozin and conventional treatment groups were 113±20 and 110±27 cm <superscript>3</superscript> , respectively. Not only HbA1c and plasma level of TNF-α but also echocardiography findings including left atrial dimension and P-wave indices were comparable between the two groups. After 6 months, plasma level of TNF-α as well as EAT volume significantly decreased in the dapagliflozin group only. P-wave dispersion and P-wave variation significantly decreased in the dapagliflozin group only (-9.2±8.7 vs. 5.9±19.9 ms, p=0.01; -3.5±3.5 vs. 1.7±5.9 ms, p=0.01). The change in P-wave dispersion correlated with changes in EAT volume and plasma level of TNF-α. In multivariate analysis, the change in EAT volume was an independent determinant of the change in P-wave dispersion.<br />Conclusion: Dapagliflozin reduced plasma level of TNF-α, EAT volume, and P-wave indices, such as P-wave dispersion. The changes in P-wave indices were especially associated with changes in EAT volume.The number and date of registration: UMIN000035660, 24/Jan/2019.
- Subjects :
- Adipose Tissue pathology
Aged
Benzhydryl Compounds pharmacology
Coronary Artery Disease complications
Coronary Artery Disease drug therapy
Coronary Artery Disease pathology
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 drug therapy
Diabetes Mellitus, Type 2 pathology
Female
Glucosides pharmacology
Humans
Male
Middle Aged
Pericardium pathology
Sodium-Glucose Transporter 2 Inhibitors pharmacology
Adipose Tissue drug effects
Benzhydryl Compounds therapeutic use
Glucosides therapeutic use
Pericardium drug effects
Sodium-Glucose Transporter 2 Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1880-3873
- Volume :
- 27
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of atherosclerosis and thrombosis
- Publication Type :
- Academic Journal
- Accession number :
- 32115470
- Full Text :
- https://doi.org/10.5551/jat.48009